Cell Culture Media, Supplements, and Reagents
Medchemexpress LLC IRAK4-IN-4 50mg | 1850276-58-2 | 50 MG
IRAK4-IN-4 is a research small-molecule inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) with additional activity against cyclic GMP-AMP synthase (cGAS). Supplied as a light yellow solid with reported high purity, it is used in biochemical and cellular studies to probe IRAK4- and cGAS-mediated signaling pathways in inflammation and autoimmune disease research.
- Potent IRAK4 inhibition (IC50 2.8 nM).
- Potent cGAS inhibition (IC50 2.1 nM).
- High purity (99.6%).
- Light yellow solid physical form.
- Molecular weight 340.37 g/mol.
- Suitable for preclinical biochemical and cellular assays.
- Available in multiple small milligram pack sizes for research use.
Apexbio Technology LLC Cetylpyridinium Chloride 123-03-5 50mg
Cetylpyridinium chloride (CAS 123-03-5) is a small-molecule inhibitor targeting microbial cell membranes It is designed to disrupt bacterial lipid bilayers thereby altering membrane permeability and inhibiting microbial viability Cetylpyridinium chloride exerts its biological activity primarily through membrane destabilization via positively charged cetylpyridinium ions interacting with negatively charged microbial surfaces In in vitro studies cetylpyridinium chloride demonstrates inhibitory activity with IC50 values ranging approximately between 0 5 to 10 M depending on microbial strain type and experimental conditions Based on these pharmacological properties cetylpyridinium chloride holds research potential in evaluating oral microbial inhibition biofilm formation interference and cell membrane-targeted antibacterial strategies
Chem-Impex International, Inc. Tetracycline hydrochloride | 64-75-5 | MFCD00078142 | 25G
Tetracycline hydrochloride, 64-75-5, MFCD00078142, 25G
Medchemexpress LLC Heparan sulfate | 9050-30-0 | 593.47 (monomer) | C12H19NO20S3 (monomer) | 50 MG
Heparan sulfate is a naturally occurring linear glycosaminoglycan used as a research reagent to study growth factor signaling, extracellular matrix interactions, and enzymatic degradation. It is supplied as a purified polysaccharide suitable for biochemical assays and cell-based studies.
- Naturally occurring linear glycosaminoglycan.
- Used to study growth factor and extracellular matrix interactions.
- Soluble in water for assay preparation.
- Monomer formula C12H19NO20S3; monomer MW 593.47.
- Available in multiple package sizes including 50 mg.
Medchemexpress LLC Vancomycin hydrochloride | 1404-93-9 | 99.4% | 1485.71 | 1 ML
Vancomycin hydrochloride is an antibiotic used for treating bacterial infections. Its mechanism of action involves inhibiting the second stage of cell wall synthesis in susceptible bacteria. Additionally, vancomycin modifies the permeability of the cell membrane and selectively prevents ribonucleic acid synthesis. This product is for research use only and has not been fully validated for medical applications.
- Inhibits bacterial cell wall synthesis
- Modifies cell membrane permeability
- Selectively inhibits ribonucleic acid synthesis
- Acts as an antibiotic
- Relevant for autophagy research
- Applicable in infection research
- Used in cancer research
Medchemexpress LLC TTA-A2 | 953778-63-7 | 99.3% | 378.39 | 100 MG
TTA-A2 is a potent, selective, and orally active T-type voltage-gated calcium channel antagonist with reduced pregnane X receptor (PXR) activation. It is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels with IC50 values of 89 nM and 92 nM, respectively, at -80 and -100 mV holding potentials. TTA-A2 can be used for the research of various human neurological diseases, including sleep disorders and epilepsy.
- Potent, selective, orally active T-type voltage-gated calcium channel antagonist.
- Reduced pregnane X receptor (PXR) activation.
- Equally potent against Cav3.1 and Cav3.2 channels.
- Used in research for neurological diseases, sleep disorders, and epilepsy.
- Exhibits high affinity in α1I binding assay (Ki of 1.2 nM).
- Excellent selectivity over hERG potassium and L-type calcium channels.
- Modifies sleep architecture in rats and mice.
Medchemexpress LLC D-α-Hydroxyglutaric acid | 13095-47-1 | 148.11 | 10MG
D-α-Hydroxyglutaric acid is the primary metabolite accumulating in D-2-hydroxyglutaric aciduria, a neurometabolic disease. It acts as a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases. This compound also enhances reactive oxygen species (ROS) production, binds to and inhibits ATP synthase, and suppresses mTOR signaling. It accumulates in human cancers with specific mutations in IDH1 and IDH2 genes.
- Primary metabolite in D-2-hydroxyglutaric aciduria
- Weak competitive antagonist of α-ketoglutarate (α-KG)
- Inhibits multiple α-KG-dependent dioxygenases
- Increases reactive oxygen species (ROS) production
- Binds and inhibits ATP synthase
- Inhibits mTOR signaling
- Accumulates in human cancers with IDH1 and IDH2 mutations
Medchemexpress LLC Anisomycin | 22862-76-6 | 265.31 | 5 MG
Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. It is also a JNK activator, increasing phospho-JNK, and functions as a bacterial antibiotic.
- Potent protein synthesis inhibitor
- Interferes with protein and DNA synthesis
- Inhibits peptidyl transferase or the 80S ribosome system
- JNK activator
- Bacterial antibiotic
Medchemexpress LLC RG2833 | 1215493-56-3 | 99.26% | 339.43 | 500 MG
RG2833 is a brain-penetrant HDAC inhibitor with IC50s of 60 nM and 50 nM for HDAC1 and HDAC3, respectively. The Ki values for HDAC1 and HDAC3 are 32 nM and 5 nM, respectively. It is for research use only.
- Brain-penetrant HDAC inhibitor.
- IC50s: 60 nM for HDAC1, 50 nM for HDAC3.
- Ki values: 32 nM for HDAC1, 5 nM for HDAC3.
- Highly active in the tested concentration range from 1 to 10 μM.
- Induces sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model.
- Produces significant increases in brain aconitase enzyme activity and reduces neuronal pathology of the dorsal root ganglia (DRG).
- Corrects frataxin deficiency in the brain and heart of KIKI mice.
- Improves motor coordination of YG8R FRDA mice and increases frataxin protein expression in their brain.
- Attenuates L-DOPA-induced dyskinesia in MPTP-lesioned marmosets.
Medchemexpress LLC Topilutamide | 260980-89-0 | 99.9% | 403.23 | 50 MG
Topilutamide is a topical nonsteroidal antiandrogen (NSAA). It is used in the treatment of prostate cancer. Prostate cancer is the most common cancer and one of the leading causes of cancer deaths in men, and first-generation NSAAs like Topilutamide are used to treat metastatic prostate cancer.
- Topical nonsteroidal antiandrogen (NSAA).
- Used in the treatment of prostate cancer.
- Suitable for treating metastatic prostate cancer.
Medchemexpress LLC HY-100372 5mg Medchemexpress, E4CPG CAS:170846-89-6 Purity:>98%
Medchemexpress, HY-100372 5mg E4CPG CAS:170846-89-6 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC T025 | 2407433-00-3 | 99.6% | 382.42 | 10 MG
T025 is an orally active and highly potent inhibitor of Cdc2-like kinase (CLKs). It induces caspase-3/7-mediated cell apoptosis, reduces CLK-dependent phosphorylation, and exhibits anti-proliferative activities in hematological and solid cancer cell lines. T025 primarily has anti-tumor efficiency for MYC-driven disease research.
- Orally active and highly potent inhibitor of Cdc2-like kinase (CLKs)
- Induces caspase-3/7-mediated cell apoptosis
- Reduces CLK-dependent phosphorylation
- Exhibits anti-proliferative activities in hematological and solid cancer cell lines
- Anti-tumor efficiency for MYC-driven disease research
Ubpbio Kanamycin Sulfate, 25G
Kanamycin sulfate is an aminoglycosidic antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria and mycoplasmas in cell culture.
Medchemexpress LLC HY-13735D 10mg Medchemexpress, d-Atabrine dihydrochloride CAS:56100-41-5 Purity:>98%
Medchemexpress, HY-13735D 10mg d-Atabrine dihydrochloride CAS:56100-41-5 d-Atabrine dihydrochloride is an active enantiomer of quinacrine which displays antiprion activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Medicagenic acid | 599-07-5 | MFCD02752364 | >98.0% | 488.7 g/mol | C30H48O5 | 10 MG
Medicagenic acid is a pentacyclic triterpenoid (castanogenin) isolated from the roots of Herniaria glabra and supplied for laboratory research use. It exhibits fungistatic effects against several plant pathogens and human dermatophytes and shows low inhibitory activity against enzymes including xanthine oxidase, collagenase, elastase, tyrosinase, and cholinesterases.
- High purity (>98%).
- Slightly yellow to yellow solid form.
- Stable when stored as powder at -20°C for up to 3 years and in solvent at -80°C for up to 2 years.
- Supplied in a 10 mg quantity suitable for small-scale research applications.
- Includes technical documentation such as a datasheet, certificate of analysis, and MSDS.